Drug-induced hypersensitivity syndrome (DIHS), also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe, multi-organ, adverse reaction characterized by erythema with facial oedema,
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Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Drug-induced hypersensitivity syndrome (DIHS), also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe, multi-organ, adverse reaction characterized by erythema with facial oedema, fever, lymphadenopathy, hepatitis, and leukocytosis with eosinophilia (1–3). In more than 60% of DIHS cases, human herpesvirus (HHV)-6 reactivation is observed and is associated with an unfavourable outcome (4). High-dose corticosteroid therapy is a controversial treat ment for DIHS/DRESS because patients may become susceptible to infections (5). We describe here the case of a DIHS/ DRESS patient successfully treated with high-dose intravenous immunoglobulin (IVIG) containing a high titre of anti-HHV-6 antibodies.
منابع مشابه
Drug reaction with eosinophilia and systemic symptoms: A drug-induced hypersensitivity syndrome with variable clinical features
Drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) involves a unique and severe adverse drug reaction. Patients present with fever, rash, lymphadenopathy, hematological abnormalities, systemic illness, and may suffer from prolonged courses. Although the precise pathogenesis of DRESS/DIHS is not fully understood, it is widely considered...
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© 2013 The Authors. doi: 10.2340/00015555-1363 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Drug-induced hypersensitivity syndrome (DIHS), also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe, adverse drug reaction characterized by skin rash, fever, lymphadenopathy, hepatitis and haematological abnormalities (1, 2). The presence of human ...
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